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As you know, the first medicine to radically change ideas about the methods of treatment of disorders of erectile function, was Viagra. Injection into the cavernous tissue of the penis, vacuum pumps and other invasive procedures left to the dustbin of history, replaced by a very unassuming to use and highly efficient drug. The official approval of Viagra by the U.S. quality supervision, food and drug administration (FDA) in 1998 meant that the company "Pfizer" received a monopoly on the production of effective and safe drug, which in the first year of sales brought her more than one billion (!) dollars. Such financial idyll to "Pfizer" lasted 5 years until the moment when in 2003, the pharmaceutical market has released two new drug to increase potency — Cialis (tadalafil) and Levitra (vardenafil).

In the history of the drug Cialis was a place of curiosities. In the same way as in the case of Viagra, it all started with research. In 1993, an American multinational pharmaceutical Corporation Aykos launched a full-scale study of the substances of the group of inhibitors of the enzyme phosphodiesterase type 5 (PDE5), namely IC351. Today, drugs based on inhibitors of PDE5 are the most promising means for the treatment and prevention of erectile dysfunction. But at the end of last century, the situation was fundamentally different: it is enough to say that the creation of the first drug of the group inhibitors PDE5 was happy, but still an accident (see Viagra).

Cialis: history

As well as sildenafilom, the effect of tadalafil on the potency of a man was a surprise for scientists after the substance had already been tested as a treatment for erectile dysfunction. Although scientists Aykos began his academic career in 1990, and the patent for the IC351 was received by them four years later, is still not clear who was a pioneer in the creation of the PDE5 inhibitors: pzer with its Viagra or Aykos with Cialis.

The year 1995 was marked by the beginning of clinical studies of tadalafil the first phase. In other words, the drug was first tested on humans. Testing was conducted on a small group of patients suffering from erectile dysfunction. At this stage, was demonstrated a favorable safety profile of the drug in the conditions of the proposed therapeutic schemes. Two years later, launched the second phase of clinical trials, in which tadalafil was tested in large groups of patients. Here, the scientists ' attention was focused on the effectiveness of the drug, which has proven itself in this regard at its best. In the second phase of the test was optimal therapeutic dosages of active substance. These studies lasted two years, after which Aykos has joined forces with yet another American pharmaceutical company "Eli Lilly" (there are a number of good reasons, but now not about it). The result of the joint efforts was the drug Cialis (tadalafil), the creation of which was announced at the 97th Convention of the American Association of urologists in Florida.

Cialis or Viagra

The popularity of the drug grew very quickly. Today Cialis can be bought in more than 100 countries. When compared to Viagra not to mention a number of advantages (for more details, they will be considered in the appropriate Chapter of this article). So, the effect of tadalafil is growing faster than sildenafil (15 minutes vs. 30) and is longer (36 hours vs 4-6). In this case, the reception frequency of both drugs is 1 per day so that the patient in case Cialis does not worry about planning sexual activity (because the drug in any case will act the whole day), that favorably affects the emotional state. So, if you kept the Shakespearean question "generic Cialis: to buy or not to buy?" do not even doubt "robocast" of this wonderful drug.